NMU-based murine model could aid search for immune-based treatment.

2004 APR 12 - (NewsRx.com & NewsRx.net) -- A novel murine model of breast cancer could facilitate the search for improved immune-based treatments.

"Improvement of immunotherapy-based protocols in cancer requires a better understanding of tumor microenvironment and tumor-host interaction," oncologists in Uruguay argued. "Stromal and immune cells and molecules such as cytokines, chemokines, growth factors and metalloproteases mediate tumor-host interaction determining, at least in part, tumor development."

In a recent study, M. Hill and colleagues at the Facultad de Medicina in Montevideo "used an immunohistochemical approach to explore leukocyte …